Regulation of the Wilms' tumor gene during spermatogenesis
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms of gene regulation during Drosophila spermatogenesis.
The differentiation of sperm from morphologically unremarkable cells into highly specialised free-living, motile cells requires the co-ordinated action of a very large number of gene products. The expression of these products must be regulated in a developmental context to ensure normal cellular differentiation. Many genes essential for spermatogenesis are not used elsewhere in the animal, or a...
متن کاملTranscriptional regulation during Drosophila spermatogenesis
Drosophila spermatogenesis has become a paradigmatic system for the study of mechanisms that regulate adult stem cell maintenance, proliferation and differentiation. The dramatic cellular differentiation process from germline stem cell (GSC) to mature sperm is accompanied by dynamic changes in gene expression, which are regulated at transcriptional, post-transcriptional (including translational...
متن کاملDifferential regulation of the Wilms' tumor gene, WT1, during differentiation of embryonal carcinoma and embryonic stem cells.
The expression pattern of the Wilms' tumor suppressor gene, WT1, during embryonal development suggests a role for the WT1 proteins in the differentiation of specific tissues. This notion is supported by the observation that WT1 knock-out mice fall to develop kidneys and gonads. We describe here the changes in the expression and DNA binding activity of the WT1 gene product in P19 embryonal carci...
متن کاملIn silico screening of G-Quadruplex Structures in Wilms tumor 1 Gene Promoter
Introduction: X-ray diffraction studies have revealed that guanines in a DNA stands may be arranged in quartet and form a structure called G-quadruplexs. Bioinformatics studies suggested the formation of G-quadruplex structure in human crucial genes, including Wilms tumor 1 (WT1). The aim of this study was to in silico analysis of the guanine-rich sequence in the promoter region of the WT1 gene...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 1996
ISSN: 1058-8388,1097-0177
DOI: 10.1002/(sici)1097-0177(199612)207:4<372::aid-aja2>3.3.co;2-7